Recombinant Human KIR3DL1 protein (ab51218)

Overview

  • Product name
    Recombinant Human KIR3DL1 protein
  • Protein length
    Protein fragment

Description

  • Nature
    Recombinant
  • Source
    Escherichia coli
  • Amino Acid Sequence
    • Accession
    • Species
      Human
    • Sequence
      MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSTSGT IDKLDIEFHL WCSNKKNAAV MDQEPAGNRT ANSEDSDEQD PEEVTYAQLD HCVFTQRKIT RPSQRPKTPP TDTILYTELP NAKPRSKVVS CP
    • Molecular weight
      15 kDa including tags
    • Amino acids
      361 to 444
    • Tags
      His tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab51218 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

  • Purity
    > 95 % SDS-PAGE.
    A His-tag fusion protein of KIR3DL1 cytoplasmic tail was overexpressed as insoluble protein aggregates (inclusion bodies). This protein was purified by FPLC gel-filtration chromatography, after refolding of the isolated inclusion bodies in a redox buffer.
  • Form
    Liquid
  • Additional notes


    The cytoplasmic tail of KIR3DL1, which contains two immunoreceptor tyrosine-based inhibition motifs (ITIMs), mediates inhibitory signal transduction that prevents killer cell-mediated cytotoxicity.

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: 25mM Tris HCl, 100mM Sodium chloride, pH 7.5

General Info

  • Alternative names
    • AMB11
    • CD158 antigen-like family member E
    • CD158e
    • CD158e antigen
    • CD158E1
    • CD158E1/2
    • CD158E2
    • CL11
    • CL2
    • HLA-BW4-specific inhibitory NK cell receptor
    • KI3L1_HUMAN
    • killer cell immunoglobulin like receptor
    • Killer cell immunoglobulin like receptor three domains , short cytoplasmic tail, 1
    • Killer cell immunoglobulin like receptor three domains long cytoplasmic tail 1
    • Killer cell immunoglobulin-like receptor 3DL1
    • KIR
    • KIR antigen 3DL1
    • KIR G1
    • Kir3dl1
    • KIR3DS1
    • Kirl1
    • Kirl2
    • Krl1
    • MGC119726
    • MGC119728
    • MGC126589
    • MGC126591
    • MHC class I NK cell receptor
    • Natural killer associated transcript 3
    • Natural killer cell inhibitory receptor
    • Natural killer-associated transcript 3
    • NK receptor
    • NK-associated transcript 10
    • NK-associated transcript 3
    • NK-associated transcript 3delIg1
    • NKAT-3
    • NKAT10
    • NKAT3
    • NKB1
    • NKB1B
    • p70 killer cell inhibitory receptor
    • p70 natural killer cell receptor clones CL 2/CL 11
    • p70 natural killer cell receptor clones CL-2/CL-11
    • p70 NK receptor CL-2/CL-11
    see all
  • Function
    Receptor on natural killer (NK) cells for HLA Bw4 allele. Inhibits the activity of NK cells thus preventing cell lysis.
  • Sequence similarities
    Belongs to the immunoglobulin superfamily.
    Contains 3 Ig-like C2-type (immunoglobulin-like) domains.
  • Cellular localization
    Cell membrane.
  • Information by UniProt

Images

  • 14% SDS-PAGE gel loaded with ab51218, recombinant human KIR3DL1 protein (His tag).
    Predicted molecular weight 15kDa.

References

ab51218 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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