Recombinant Human Kir4.1 protein (ab114456)

Overview

  • Product nameRecombinant Human Kir4.1 protein
  • Protein lengthProtein fragment

Description

  • NatureRecombinant
  • SourceWheat germ
  • Amino Acid Sequence
    • AccessionP78508
    • SpeciesHuman
    • SequenceDFELVLILSGTVESTSATCQVRTSYLPEEILWGYEFTPAISLSASGKYIA DFSLFDQVVKVASPSGLRDSTVRYGDPEKLKLEESLREQAEKEGSALSVR ISNV
    • Molecular weight37 kDa including tags
    • Amino acids276 to 379

Specifications

Our Abpromise guarantee covers the use of ab114456 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Western blot

    SDS-PAGE

    ELISA

  • FormLiquid
  • Additional notesProtein concentration is above or equal to 0.05 mg/ml.
    ab114456 is best used within three months from the date of receipt.
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.79% Tris HCl, 0.3% Glutathione

General Info

  • Alternative names
    • ATP dependent inwardly rectifying potassium channel Kir4.1
    • ATP sensitive inward rectifier potassium channel 10
    • ATP-dependent inwardly rectifying potassium channel Kir4.1
    • ATP-sensitive inward rectifier potassium channel 10
    • BIRK10
    • Glial ATP dependent inwardly rectifying potassium channel KIR4.1
    • Inward rectifier K(+) channel Kir1.2
    • Inward rectifier K+ channel KIR1.2
    • Inwardly rectifying potassium channel Kir1.2
    • inwardly rectifying subfamily J member 10
    • KCJ10_HUMAN
    • KCNJ 10
    • Kcnj10
    • KCNJ13 PEN
    • KIR1.2
    • KIR4.1
    • Potassium channel
    • Potassium channel inwardly rectifying subfamily J member 10
    • Potassium inwardly rectifying channel subfamily J member 10
    • SESAME
    see all
  • FunctionMay be responsible for potassium buffering action of glial cells in the brain. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium and cesium (By similarity). In the kidney, together with KCNJ16, mediates basolateral K(+) recycling in distal tubules; this process is critical for Na(+) reabsorption at the tubules.
  • Tissue specificityExpressed in kidney (at protein level).
  • Involvement in diseaseSeizures, sensorineural deafness, ataxia, mental retardation, and electrolyte imbalance
  • Sequence similaritiesBelongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ10 subfamily.
  • Cellular localizationMembrane. Basolateral cell membrane. In kidney distal convoluted tubules, located in the basolateral membrane where it colocalizes with KCNJ16.
  • Information by UniProt

Recombinant Human Kir4.1 protein images

  • ab114456 analysed on a 12.5% SDS-PAGE stained with Coomassie Blue.

References for Recombinant Human Kir4.1 protein (ab114456)

ab114456 has not yet been referenced specifically in any publications.

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Unfortunately, we cannot sell this product to you because of Dry Ice shipping restriction to Norway.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"