The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Additional notesProtein concentration is above or equal to 0.05 mg/ml. Best use within three months from the date of receipt of this protein.
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Preparation and Storage
Stability and Storage
Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
pH: 8.00 Constituents: 0.3% Glutathione, 0.79% Tris HCl
ATP sensitive inward rectifier potassium channel 11
Beta cell inward rectifier subunit
Inward rectifier K(+) channel Kir6.2
Inwardly rectifying potassium channel KIR6.2
Potassium channel inwardly rectifing subfamily J member 11
Potassium channel, inwardly rectifying subfamily J member 11
Potassium inwardly rectifying channel J11
RelevanceATP-sensitive potassium (K(ATP)) channels are found in endocrine cells, neurons and both smooth and striated muscle, where they play an important role in controlling insulin secretion and vascular tone, and protect neurons under metabolic stress. Kir6.2 is a member of the inward rectifier potassium channel family, which is characterised by a greater tendency to allow potassium flow into the cell rather than out of it. It associates with the sulphonylurea receptor SUR1/ABCC8 to form a subfamily of K(ATP) channels that, when mutated or misregulated, are associated with forms of hyperinsulinemic hypoglycemia, neonatal diabetes, or pre-disposition to type 2 diabetes mellitus.
Cellular localizationCell Membrane; Multi-pass membrane protein
Recombinant Human Kir6.2 protein images
SDS-PAGE - Kir6.2 protein (ab114436)
ab114436 analysed on a 12.5% SDS-PAGE gel stained with Coomassie Blue.
References for Recombinant Human Kir6.2 protein (ab114436)
has not yet been referenced specifically in any publications.
Publishing research using ab114436? Please let us know so that we can cite the reference in this datasheet.
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