Overview

Description

  • NatureRecombinant
  • SourceEscherichia coli
  • Amino Acid Sequence
    • AccessionQ15726
    • SpeciesHuman
    • SequenceMEPLEKVASV GNSRPTGQQL ESLGLLAPGE QSLPCTERKP AATARLSRRG TSLSPPPESS GSPQQPGLSA PHSRQIPAPQ GAVLVQREKD LPNYNWNSFG LRFGKREAAP GNHGRSAGRG
    • Molecular weight13 kDa
    • Amino acids20 to 138

Specifications

Our Abpromise guarantee covers the use of ab117209 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

  • Purity> 90 % SDS-PAGE.
    ab117209 was purified by proprietary chromatographic techniques and filter sterilized.
  • FormLiquid
  • Additional notesab117209 although stable at 4°C for 4 weeks, should be stored desiccated below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Please see notes section.

    pH: 8.00
    Constituents: 0.32% Tris HCl, 0.02% DTT, 10% Glycerol

General Info

  • Alternative names
    • KISS 1
    • KiSS 1 metastasis suppressor
    • Kiss1
    • KISS1_HUMAN
    • Kisspeptin
    • Kisspeptin 1
    • Kisspeptin 10
    • Kisspeptin 13
    • Kisspeptin 14
    • Kisspeptin-1
    • Kisspeptin-10
    • Kisspeptin-54
    • Kisspeptin1
    • Malignant melanoma metastasis suppressor
    • Metastasis suppressor KiSS 1
    • Metastasis suppressor KiSS1
    • Metastin
    • MGC39258
    see all
  • FunctionMetastasis suppressor protein in malignant melanomas and in some breast cancers. May regulate events downstream of cell-matrix adhesion, perhaps involving cytoskeletal reorganization. Generates a C-terminally amidated peptide, metastin which functions as the endogenous ligand of the G-protein coupled receptor GPR54. Activation of the receptor inhibits cell proliferation and cell migration, key characteristics of tumor metastasis. Kp-10 is a decapeptide derived from the primary translation product, isolated in conditioned medium of first trimester trophoblast. Kp-10, but not other kisspeptins, increased intracellular Ca(2+) levels in isolated first trimester trophoblasts. Kp-10 is a paracrine/endocrine regulator in fine-tuning trophoblast invasion generated by the trophoblast itself. The receptor is also essential for normal gonadotropin-released hormone physiology and for puberty. The hypothalamic KiSS1/GPR54 system is a pivotal factor in central regulation of the gonadotropic axis at puberty and in adulthood.
  • Tissue specificityVery high expression in placenta, with the next highest level in testis and moderate levels in pancreas, liver, small intestine and brain at much lower levels. Expression levels increased in both early placentas and molar pregnancies and are reduced in choriocarcinoma cells. Expressed at higher levels in first trimester trophoblasts than at term of gestation, but only expressed in the villous trophoblast.
  • Sequence similaritiesBelongs to the KISS1 family.
  • Post-translational
    modifications
    Processed by MMP2 and MMP9.
  • Cellular localizationSecreted.
  • Information by UniProt

References for Recombinant Human Kisspeptin protein (ab117209)

This product has been referenced in:
  • Stathaki M  et al. Kisspeptin effect on endothelial monocyte activating polypeptide II (EMAP-II)-associated lymphocyte cell death and metastases in colorectal cancer patients. Mol Med 20:80-92 (2014). Read more (PubMed: 24395571) »

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"