Additional sequence informationab91256 is a 483 amino acid protein, including a 13-residue C- term TAT peptide. ab91256 is a mixture of the expected sequence beginning at Met1 and a truncated isoform beginning at Tyr54.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Endotoxin level< 0.100 Eu/µg
% SDS-PAGE. Purity greater than 90% by SDS-PAGE gel and HPLC analyses
Additional notesEndotoxin level is less than 0.1 ng per µg (1EU/µg).
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Preparation and Storage
Stability and Storage
Shipped at 4°C.
ReconstitutionCentrifuge the vial prior to opening. Reconstitute in water
to a concentration of 0.1-1.0 mg/ml. Do not vortex. This
solution can be stored at 2-8°C; for up to 1 week. For
extended storage, it is recommended to further dilute in a
buffer containing a carrier protein (example 0.1% BSA)
and store in working aliquots at -20°C; to -80°C;
Endothelial Kruppel like zinc finger protein
Epithelial zinc finger protein EZF
gut Kruppel-like factor
Gut-enriched krueppel-like factor
Krueppel-like factor 4
Kruppel like factor 4 (Epithelial zinc finger protein EZF) (Gut enriched Krueppel like factor)
Kruppel like factor 4 (gut)
FunctionTranscription factor; can act both as activator and as repressor. Binds the 5'-CACCC-3' core sequence. Binds to the promoter region of its own gene and can activate its own transcription. Regulates the expression of key transcription factors during embryonic development. Plays an important role in maintaining embryonic stem cells, and in preventing their differentiation. Required for establishing the barrier function of the skin and for postnatal maturation and maintenance of the ocular surface. Involved in the differentiation of epithelial cells and may also function in skeletal and kidney development. Contributes to the down-regulation of p53/TP53 transcription.
Sequence similaritiesBelongs to the krueppel C2H2-type zinc-finger protein family. Contains 3 C2H2-type zinc fingers.
Domainthe 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors.