Recombinant Human KMT3C / SMYD2 protein (ab107699)

Overview

Description

  • Nature
    Recombinant
  • Source
    Baculovirus infected Sf9 cells
  • Amino Acid Sequence
    • Accession
    • Species
      Human
    • Molecular weight
      70 kDa including tags
    • Amino acids
      1 to 371

Associated products

Specifications

Our Abpromise guarantee covers the use of ab107699 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

    Western blot

  • Purity
    > 85 % SDS-PAGE.
    The purity was determined to be >85% by densitometry
  • Form
    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: 25% Glycerol, 50mM Sodium chloride, 50mM Tris HCl, 10mM Glutathione, 0.25mM DTT, 0.1mM EDTA, 0.1mM PMSF, pH 7.5

General Info

  • Alternative names
    • Histone methyltransferase SMYD2
    • HSKM B
    • HSKM-B
    • HSKMB
    • KMT3C
    • Lysine N-methyltransferase 3C
    • MGC119305
    • N lysine methyltransferase SMYD2
    • N-lysine methyltransferase SMYD2
    • SET and MYND domain containing 2
    • SET and MYND domain containing protein 2
    • SET and MYND domain-containing protein 2
    • Smyd2
    • SMYD2_HUMAN
    • Zinc finger MYND domain containing 14
    • ZMYND14
    see all
  • Function
    Protein-lysine N-methyltransferase that methylates both histones and non-histone proteins. Specifically methylates histone H3 'Lys-4' (H3K4me) and dimethylates histone H3 'Lys-36' (H3K36me2). Has also methyltransferase activity toward non-histone proteins such as p53/TP53 and RB1. Monomethylates 'Lys-370' of p53/TP53, leading to decreased DNA-binding activity and subsequent transcriptional regulation activity of p53/TP53. Monomethylates 'Lys-860' of RB1/RB.
  • Sequence similarities
    Contains 1 MYND-type zinc finger.
    Contains 1 SET domain.
  • Cellular localization
    Cytoplasm > cytosol. Nucleus.
  • Information by UniProt

Images

  • SDS-PAGE analysis of ab107699

References

ab107699 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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