Recombinant Human KMT4 / Dot1L protein (ab80254)

Overview

Description

  • Nature
    Recombinant
  • Source
    Escherichia coli
  • Amino Acid Sequence
    • Species
      Human
    • Amino acids
      2 to 416

Specifications

Our Abpromise guarantee covers the use of ab80254 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

  • Form
    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on Dry Ice. Upon delivery aliquot. Store at -80°C. Avoid freeze / thaw cycle.

    Preservative: None
    Constituents: 20% Glycerol, 0.05% Tween 20, 3mM DTT, 25mM Tris HCl, 100mM Sodium chloride, pH 7.5

General Info

  • Alternative names
    • Disrupter of telomere silencing protein 1
    • DOT 1
    • DOT1
    • DOT1 like
    • DOT1 like histone H3 methyltransferase
    • DOT1 like histone H3 methyltransferase (S. cerevisiae)
    • DOT1 like histone H3K79 methyltransferase
    • DOT1 like protein
    • DOT1, S. cerevisiae, homolog of
    • DOT1-like protein
    • DOT1L
    • DOT1L_HUMAN
    • EC 2.1.1.43
    • H3 K79 HMTase
    • H3 lysine-79 specific
    • H3-K79-HMTase
    • Histone H3 K79 methyltransferase
    • Histone H3 methyltransferase
    • Histone H3 methyltransferase DOT1-like
    • Histone H3-K79 methyltransferase
    • Histone lysine N methyltransferase H3 lysine 79 specific
    • Histone methyltransferase DOT1L
    • Histone-lysine N-methyltransferase
    • KIAA1814
    • KMT4
    • Lysine N methyltransferase 4
    • Lysine N-methyltransferase 4
    see all
  • Function
    Histone methyltransferase. Methylates 'Lys-79' of histone H3. Nucleosomes are preferred as substrate compared to free histones. Binds to DNA.
  • Sequence similarities
    Belongs to the class I-like SAM-binding methyltransferase superfamily. DOT1 family.
    Contains 1 DOT1 domain.
  • Cellular localization
    Nucleus.
  • Information by UniProt

Images

  • SDS-PAGE showing ab80254 at approximately 73kDa (5µg).

References

ab80254 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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