Recombinant Human KMT5C/SUV4-20h2 protein (ab80290)

Overview

  • Product name
    Recombinant Human KMT5C/SUV4-20h2 protein
  • Protein length
    Protein fragment

Description

  • Nature
    Recombinant
  • Source
    Escherichia coli
  • Amino Acid Sequence
    • Species
      Human
    • Amino acids
      2 to 280

Specifications

Our Abpromise guarantee covers the use of ab80290 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

  • Purity
    > 90 % SDS-PAGE.

  • Form
    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on Dry Ice. Upon delivery aliquot. Store at -80°C. Avoid freeze / thaw cycle.

    Preservative: None
    Constituents: 30% Glycerol, 0.05% Tween 20, 3mM DTT, 25mM Tris HCl, 100mM Sodium chloride, pH 8.0

General Info

  • Alternative names
    • FLJ98627
    • Histone lysine N methyltransferase SUV420H2
    • Histone-lysine N-methyltransferase SUV420H2
    • KMT5C
    • Lysine N methyltransferase 5C
    • Lysine N-methyltransferase 5C
    • MGC2705
    • Su(var)4 20 homolog 2
    • Su(var)4-20 homolog 2
    • Suppressor of variegation 4 20 homolog 2
    • Suppressor of variegation 4-20 homolog 2
    • Suv4 20h2
    • Suv4-20h2
    • SUV420H2
    • SV422_HUMAN
    see all
  • Function
    Histone methyltransferase that specifically trimethylates 'Lys-20' of histone H4. H4 'Lys-20' trimethylation represents a specific tag for epigenetic transcriptional repression. Mainly functions in pericentric heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin in these regions. SUV420H1 is targeted to histone H3 via its interaction with RB1 family proteins (RB1, RBL1 and RBL2).
  • Sequence similarities
    Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar4-20 subfamily.
    Contains 1 SET domain.
  • Cellular localization
    Nucleus. Chromosome. Associated with pericentric heterochromatin. CBX1 and CBX5 are required for the localization to pericentric heterochromatin.
  • Information by UniProt

Images

  • 10% SDS-PAGE showing ab80290 at approximately 58kDa (5µg).

References

ab80290 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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