Recombinant Human l Afadin protein (ab91389)

Overview

  • Product name
    Recombinant Human l Afadin protein
  • Protein length
    Protein fragment

Description

  • Nature
    Recombinant
  • Source
    Escherichia coli
  • Amino Acid Sequence
    • Species
      Human
    • Amino acids
      1 to 141

Specifications

Our Abpromise guarantee covers the use of ab91389 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

  • Purity
    > 95 % SDS-PAGE.

  • Form
    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.

    Preservative: None
    Constituents: 50% Glycerol, 50mM Sodium chloride, 25mM HEPES, 1mM EDTA, pH 7.5

General Info

  • Alternative names
    • AF6
    • AFAD_HUMAN
    • Afadin
    • ALL1-fused gene from chromosome 6 protein
    • Mllt4
    • Protein Af-6
    • Protein AF6
    see all
  • Function
    Belongs to an adhesion system, probably together with the E-cadherin-catenin system, which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs). Nectin- and actin-filament-binding protein that connects nectin to the actin cytoskeleton.
  • Involvement in disease
    Note=A chromosomal aberration involving MLLT4 is associated with acute leukemias. Translocation t(6;11)(q27;q23) with MLL/HRX. The result is a rogue activator protein.
  • Sequence similarities
    Contains 1 dilute domain.
    Contains 1 FHA domain.
    Contains 1 PDZ (DHR) domain.
    Contains 2 Ras-associating domains.
  • Domain
    The PDZ/DHR domain interacts with the C-terminus of nectin and the Pro-rich N-terminus domain interacts with F-actin.
  • Cellular localization
    Cell junction > adherens junction. Not found at cell-matrix AJs.
  • Information by UniProt

References for Recombinant Human l Afadin protein (ab91389)

ab91389 has not yet been referenced specifically in any publications.

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