Recombinant Human l Afadin protein (ab91389)

Overview

  • Product nameRecombinant Human l Afadin protein
  • Protein lengthProtein fragment

Description

  • NatureRecombinant
  • SourceEscherichia coli
  • Amino Acid Sequence
    • SpeciesHuman
    • Amino acids1 to 141

Specifications

Our Abpromise guarantee covers the use of ab91389 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

  • Purity> 95 % SDS-PAGE.

  • FormLiquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.

    Preservative: None
    Constituents: 50% Glycerol, 50mM Sodium chloride, 25mM HEPES, 1mM EDTA, pH 7.5

General Info

  • Alternative names
    • AF6
    • AFAD_HUMAN
    • Afadin
    • ALL1-fused gene from chromosome 6 protein
    • Mllt4
    • Protein Af-6
    • Protein AF6
    see all
  • FunctionBelongs to an adhesion system, probably together with the E-cadherin-catenin system, which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs). Nectin- and actin-filament-binding protein that connects nectin to the actin cytoskeleton.
  • Involvement in diseaseNote=A chromosomal aberration involving MLLT4 is associated with acute leukemias. Translocation t(6;11)(q27;q23) with MLL/HRX. The result is a rogue activator protein.
  • Sequence similaritiesContains 1 dilute domain.
    Contains 1 FHA domain.
    Contains 1 PDZ (DHR) domain.
    Contains 2 Ras-associating domains.
  • DomainThe PDZ/DHR domain interacts with the C-terminus of nectin and the Pro-rich N-terminus domain interacts with F-actin.
  • Cellular localizationCell junction > adherens junction. Not found at cell-matrix AJs.
  • Information by UniProt

References for Recombinant Human l Afadin protein (ab91389)

ab91389 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab91389.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"