Recombinant Human Laminin 2 alpha protein (ab114155)

Overview

  • Product nameRecombinant Human Laminin 2 alpha protein
  • Protein lengthProtein fragment

Description

  • NatureRecombinant
  • SourceWheat germ
  • Amino Acid Sequence
    • AccessionP24043
    • SpeciesHuman
    • SequenceDAGVPGHLCDGQWHKVTANKIKHRIELTVDGNQVEAQSPNPASTSADTND PVFVGGFPDDLKQFGLTTSIPFRGCIRSLKLTKGTGKPLEVNFAKALELR GVQPVSCPAN
    • Molecular weight38 kDa including tags
    • Amino acids3013 to 3122

Specifications

Our Abpromise guarantee covers the use of ab114155 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Western blot

    ELISA

    SDS-PAGE

  • FormLiquid
  • Additional notesprotein concentration is above or equal to 0.05 mg/ml.
    ab114155 is best used within three months from the date of receipt.
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.3% Glutathione, 0.79% Tris HCl

General Info

  • Alternative names
    • LAMA 2
    • LAMA2
    • LAMA2_HUMAN
    • Laminin alpha 2
    • Laminin alpha 2 (merosin congenital muscular dystrophy)
    • Laminin alpha 2 chain
    • Laminin alpha 2 subunit
    • Laminin M
    • Laminin M chain
    • Laminin subunit alpha-2
    • Laminin-12 subunit alpha
    • Laminin-2 subunit alpha
    • Laminin-4 subunit alpha
    • LAMM
    • Merosin heavy chain
    see all
  • FunctionBinding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.
  • Tissue specificityPlacenta, striated muscle, peripheral nerve, cardiac muscle, pancreas, lung, spleen, kidney, adrenal gland, skin, testis, meninges, choroid plexus, and some other regions of the brain; not in liver, thymus and bone.
  • Involvement in diseaseDefects in LAMA2 are the cause of merosin-deficient congenital muscular dystrophy type 1A (MDC1A) [MIM:607855]. MDC1A is characterized by difficulty walking, hypotonia, proximal weakness, hyporeflexia, and white matter hypodensity on MRI.
  • Sequence similaritiesContains 17 laminin EGF-like domains.
    Contains 5 laminin G-like domains.
    Contains 2 laminin IV type A domains.
    Contains 1 laminin N-terminal domain.
  • DomainThe alpha-helical domains I and II are thought to interact with other laminin chains to form a coiled coil structure.
    Domains VI, IV and G are globular.
  • Cellular localizationSecreted > extracellular space > extracellular matrix > basement membrane. Major component.
  • Information by UniProt

Recombinant Human Laminin 2 alpha protein images

  • 12.5% SDS-PAGE analysis of ab114155, stained with Coomassie Blue.

References for Recombinant Human Laminin 2 alpha protein (ab114155)

ab114155 has not yet been referenced specifically in any publications.

Product Wall

The human Laminin 2 alpha protein fragment ab114155 is not the full-length protein. It is a fragment, from amino acids 3013 - 3122 of the sequence given at the UniProt database entry for human Laminin subunit alpha-2, http://www.uniprot.org/uniprot/P24...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"