Overview

Description

  • Nature
    Recombinant
  • Source
    Wheat germ
  • Amino Acid Sequence
    • Accession
    • Species
      Human
    • Sequence
      MNPNCARCGKIVYPTEKVNCLDKFWHKACFHCETCKMTLNMKNYKGYEKK PYCNAHYPKQSFTMVADTPENLRLKQQSRLQSQVRYKEEFEKNKGKGFSV VADTPELQRIKKTQDQISNIKYHEEFEKSRMGPSGGEGMEPERRDSQDGS SYRRPLEQQQPHHIPTSAPVYQQPQQQPVAQSYGGYKEPAAPVSIQRSAP GGGGKRYRAAYDYSAADEDAVSFQDGDTIVNVQQIDDGWMYGTVERTGDT GMLPANYVEAI
    • Molecular weight
      54 kDa including tags
    • Amino acids
      1 to 261

Specifications

Our Abpromise guarantee covers the use of ab114888 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    ELISA

    SDS-PAGE

    Western blot

  • Form
    Liquid
  • Additional notes
    Protein concentration is above or equal to 0.05 mg/ml. Best use within three months from the date of receipt of this protein.
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.3% Glutathione, 0.79% Tris HCl

General Info

  • Alternative names
    • LASP 1
    • LASP-1
    • LASP1
    • LASP1_HUMAN
    • LIM and SH3 domain protein 1
    • LIM and SH3 protein 1
    • Metastatic lymph node gene 50 protein
    • MLN 50
    • MLN50
    • OTTHUMP00000164238
    • OTTHUMP00000164239
    see all
  • Function
    Plays an important role in the regulation of dynamic actin-based, cytoskeletal activities. Agonist-dependent changes in LASP1 phosphorylation may also serve to regulate actin-associated ion transport activities, not only in the parietal cell but also in certain other F-actin-rich secretory epithelial cell types.
  • Sequence similarities
    Contains 1 LIM zinc-binding domain.
    Contains 2 nebulin repeats.
    Contains 1 SH3 domain.
  • Cellular localization
    Cytoplasm > cell cortex. Cytoplasm > cytoskeleton. Associated with the F-actin rich cortical cytoskeleton.
  • Information by UniProt

Images

  • 12.5% SDS-PAGE showing ab114888 at approximately 54.45kDa.
    Stained with Coomassie Blue.

References

ab114888 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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