The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Endotoxin level< 0.100 Eu/µg
Additional notesThe biological activity of this product is determined by its ability to chemoattract human monocytes using a concentration range of 10.0-100.0 ng/ml.
Concentration information loading...
Preparation and Storage
Stability and Storage
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
This product is an active protein and may elicit a biological response in vivo, handle with caution.
C-C motif chemokine 16
Chemokine (C-C motif) ligand 16
IL10 inducible chemokine
Liver CC chemokine 1 precursor
Liver expressed chemokine
Lymphocyte and monocyte chemoattractant
New CC chemokine 4
Small inducible cytokine A16 precursor
Small inducible cytokine subfamily A (Cys Cys) member 16
Small-inducible cytokine A16
FunctionShows chemotactic activity for lymphocytes and monocytes but not neutrophils. Also shows potent myelosuppressive activity, suppresses proliferation of myeloid progenitor cells. Recombinant SCYA16 shows chemotactic activity for monocytes and THP-1 monocytes, but not for resting lymphocytes and neutrophils. Induces a calcium flux in THP-1 cells that were desensitized by prior expression to RANTES.
Tissue specificityMainly expressed in liver, also found in spleen and thymus. Highly expressed in LPS- and IFN-gamma-activated monocytes, weakly in some lymphocytes, including natural killer cells, gamma-delta T-cells, and some T-cell clones.
Sequence similaritiesBelongs to the intercrine beta (chemokine CC) family.