Overview

Description

  • Nature
    Recombinant
  • Source
    Escherichia coli
  • Amino Acid Sequence
    • Accession
    • Species
      Human
    • Molecular weight
      38 kDa

Specifications

Our Abpromise guarantee covers the use of ab112725 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Western blot

  • Form
    Lyophilised
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.

    pH: 6.80
    Constituents: 1.58% Tris HCl, 3.09% DTT, 4% SDS, 0.2% Bromophenol blue, 20% Sucrose

  • Reconstitution
    Add 100ul of distilled water.

General Info

  • Alternative names
    • BRICD3
    • BRICHOS domain containing 3
    • CH-SP
    • CHM I
    • ChM-I
    • CHM1
    • chondromodulin
    • Chondromodulin I
    • Chondromodulin-1
    • Chondromodulin-I
    • Chondrosurfactant protein
    • LECT 1
    • Lect1
    • LECT1_HUMAN
    • Leukocyte cell derived chemotaxin 1
    • Multiple myeloma tumor suppressor 1
    • MYETS1
    see all
  • Function
    Bifunctional growth regulator that stimulates the growth of cultured chondrocytes in the presence of basic fibroblast growth factor (FGF) but inhibits the growth of cultured vascular endothelial cells. May contribute to the rapid growth of cartilage and vascular invasion prior to the replacement of cartilage by bone during endochondral bone development. Inhibits in vitro tube formation and mobilization of endothelial cells. Plays a role as antiangiogenic factor in cardiac valves to suppress neovascularization.
  • Tissue specificity
    Detected in cartilage and cardiac valves (at protein level). Detected in the laminae fibrosa, spongiosa and ventricularis layers of normal cardiac valves (at protein level). Expression is decreased cardiac valves of patients with valvular heart disease (at protein level). Weakly expressed in chondrosarcoma.
  • Sequence similarities
    Belongs to the chondromodulin-1 family.
    Contains 1 BRICHOS domain.
  • Developmental stage
    Expressed at 9 weeks in developing cartilagenous bone rudiments.
  • Post-translational
    modifications
    After cleavage, the post-translationally modified ChM-I is secreted as a glycoprotein.
  • Cellular localization
    Endomembrane system and Secreted. Accumulated in the inter-territorial matrix of cartilage.
  • Information by UniProt

References

ab112725 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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