Recombinant human Leptin protein (ab119739)

Overview

Description

  • NatureRecombinant
  • SourceEscherichia coli
  • Amino Acid Sequence
    • AccessionP48357
    • SpeciesHuman
    • SequenceThe sequence of the first four N-terminal amino acids was determined and was found to be Ala-Thr-Pro-Val.
    • Molecular weight25 kDa
    • Amino acids428 to 635

Specifications

Our Abpromise guarantee covers the use of ab119739 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Biological activityBiological Activity is evidenced by high affinity binding of mammalian leptins at 1:1 molar ratio
  • Applications

    Functional Studies

  • FormLyophilised
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at -20°C. Store under Desiccating conditions.

    Constituent: 0.00004% Sodium bicarbonate

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

  • ReconstitutionCentrifuge the vial prior to opening. The lyophilized Leptin Binding Domain is very soluble in water and most aqueous buffers below and above the isoelectric point (~ 5.9). The reconstituted protein should be stored at 4°C. Avoid freeze/thaw cycles.

General Info

  • Alternative names
    • FLJ94114
    • LEP
    • LEP_HUMAN
    • LEPD
    • Leptin
    • Leptin (murine obesity homolog)
    • Leptin (obesity homolog, mouse)
    • Leptin Murine Obesity Homolog
    • Leptin Precursor Obesity Factor
    • OB
    • Obese protein
    • Obese, mouse, homolog of
    • Obesity
    • Obesity factor
    • Obesity homolog mouse
    • Obesity Murine Homolog Leptin
    • OBS
    • OTTHUMP00000212285
    see all
  • FunctionMay function as part of a signaling pathway that acts to regulate the size of the body fat depot. An increase in the level of LEP may act directly or indirectly on the CNS to inhibit food intake and/or regulate energy expenditure as part of a homeostatic mechanism to maintain constancy of the adipose mass.
  • Involvement in diseaseDefects in LEP may be a cause of obesity (OBESITY) [MIM:601665]. It is a condition characterized by an increase of body weight beyond the limitation of skeletal and physical requirements, as the result of excessive accumulation of body fat.
  • Sequence similaritiesBelongs to the leptin family.
  • Cellular localizationSecreted.
  • Information by UniProt

References for Recombinant human Leptin protein (ab119739)

ab119739 has not yet been referenced specifically in any publications.

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