The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Biological Activity is evidenced by high affinity binding of mammalian leptins at 1:1 molar ratio
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Preparation and Storage
Stability and Storage
Shipped at 4°C. Store at -20°C. Store under desiccating conditions.
Constituent: 0.00004% Sodium bicarbonate
This product is an active protein and may elicit a biological response in vivo, handle with caution.
Centrifuge the vial prior to opening. The lyophilized Leptin Binding Domain is very soluble in water and most aqueous buffers below and above the isoelectric point (~ 5.9). The reconstituted protein should
be stored at 4°C. Avoid freeze/thaw cycles.
Leptin (murine obesity homolog)
Leptin (obesity homolog, mouse)
Leptin Murine Obesity Homolog
Leptin Precursor Obesity Factor
Obese, mouse, homolog of
Obesity homolog mouse
Obesity Murine Homolog Leptin
May function as part of a signaling pathway that acts to regulate the size of the body fat depot. An increase in the level of LEP may act directly or indirectly on the CNS to inhibit food intake and/or regulate energy expenditure as part of a homeostatic mechanism to maintain constancy of the adipose mass.
Involvement in disease
Defects in LEP may be a cause of obesity (OBESITY) [MIM:601665]. It is a condition characterized by an increase of body weight beyond the limitation of skeletal and physical requirements, as the result of excessive accumulation of body fat.