Overview

Description

  • Nature
    Recombinant
  • Source
    CHO cells
  • Amino Acid Sequence
    • Accession
    • Species
      Human
    • Molecular weight
      25 kDa including tags
    • Amino acids
      89 to 240
    • Tags
      DDDDK tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab109159 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

  • Endotoxin level
    < 0.100 Eu/µg
  • Purity
    > 95 % SDS-PAGE.

  • Form
    Lyophilised
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. After reconstitution store at -20ºC. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: PBS

  • Reconstitution
    Reconstitute with 100 µl sterile water. PBS containing at least 0.1% BSA should be used for further dilutions.

General Info

  • Alternative names
    • CD 258
    • CD258
    • CD258 antigen
    • Delta transmembrane LIGHT
    • Herpes virus entry mediator ligand
    • Herpesvirus entry mediator A
    • Herpesvirus entry mediator ligand
    • herpesvirus entry mediator-ligand
    • HVEM L
    • HVEM-L
    • HVEML
    • Ligand for herpesvirus entry mediator
    • LIGHT
    • LTg
    • soluble form
    • TNF14
    • TNF14_HUMAN
    • TNFSF 14
    • Tnfsf14
    • TNFSF14 protein
    • TR 2
    • TR2
    • Tumor necrosis factor (ligand) superfamily, member 14
    • Tumor necrosis factor ligand superfamily member 14
    • Tumor necrosis factor ligand superfamily, member 14
    • Tumor necrosis factor receptor like 2
    • tumor necrosis factor receptor-like 2
    • Tumor necrosis factor superfamily member 14
    • Tumor necrosis factor superfamily member LIGHT
    see all
  • Function
    Cytokine that binds to TNFRSF3/LTBR. Binding to the decoy receptor TNFRSF6B modulates its effects. Activates NFKB, stimulates the proliferation of T-cells, and inhibits growth of the adenocarcinoma HT-29. Acts as a receptor for Herpes simplex virus.
  • Tissue specificity
    Predominantly expressed in the spleen but also found in the brain. Weakly expressed in peripheral lymphoid tissues and in heart, placenta, liver, lung, appendix, and kidney, and no expression seen in fetal tissues, endocrine glands, or nonhematopoietic tumor lines.
  • Sequence similarities
    Belongs to the tumor necrosis factor family.
  • Post-translational
    modifications
    N-glycosylated.
    The soluble form of isoform 1 derives from the membrane form by proteolytic processing.
  • Cellular localization
    Cytoplasm; Secreted and Cell membrane.
  • Information by UniProt

References for Recombinant Human LIGHT protein (ab109159)

ab109159 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab109159.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

Sign up