Recombinant Human LIGHT protein (ab82123)

Overview

Description

  • Nature
    Recombinant
  • Source
    Insect cells
  • Amino Acid Sequence
    • Species
      Human
    • Sequence
      RLGEMVTRLP DGPAGSWEQL IQERRSHEVN PAAHLTGANS SLTGSGGPLL WETQLGLAFL RGLSYHDGAL VVTKAGYYYI YSKVQLGGVG CPLGLASTIT HGLYKRTPRY PEELELLVSQ QSPCGRATSS SRVWWDSSFL GGVVHLEAGE KVVVRVLDER LVRLRDGTRS YFGAFMV
    • Amino acids
      64 to 240

Specifications

Our Abpromise guarantee covers the use of ab82123 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

  • Endotoxin level
    < 0.100 Eu/µg
  • Purity
    > 95 % SDS-PAGE.
    Purity is greater than 95% by SDS-PAGE gel and HPLC analyses. Endotoxin level is less than 0.1 ng per µg (1EU/µg).
  • Form
    Lyophilised
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C.

    pH: 7.0
    Constituent: 0.33% Sodium phosphate

  • Reconstitution
    Reconstituted LIGHT is stable for at least 3 months when stored in working aliquots with a carrier protein at -20oC. Avoid repeated freeze/thaw cycles.

General Info

  • Alternative names
    • CD 258
    • CD258
    • CD258 antigen
    • Delta transmembrane LIGHT
    • Herpes virus entry mediator ligand
    • Herpesvirus entry mediator A
    • Herpesvirus entry mediator ligand
    • herpesvirus entry mediator-ligand
    • HVEM L
    • HVEM-L
    • HVEML
    • Ligand for herpesvirus entry mediator
    • LIGHT
    • LTg
    • soluble form
    • TNF14
    • TNF14_HUMAN
    • TNFSF 14
    • Tnfsf14
    • TNFSF14 protein
    • TR 2
    • TR2
    • Tumor necrosis factor (ligand) superfamily, member 14
    • Tumor necrosis factor ligand superfamily member 14
    • Tumor necrosis factor ligand superfamily, member 14
    • Tumor necrosis factor receptor like 2
    • tumor necrosis factor receptor-like 2
    • Tumor necrosis factor superfamily member 14
    • Tumor necrosis factor superfamily member LIGHT
    see all
  • Function
    Cytokine that binds to TNFRSF3/LTBR. Binding to the decoy receptor TNFRSF6B modulates its effects. Activates NFKB, stimulates the proliferation of T-cells, and inhibits growth of the adenocarcinoma HT-29. Acts as a receptor for Herpes simplex virus.
  • Tissue specificity
    Predominantly expressed in the spleen but also found in the brain. Weakly expressed in peripheral lymphoid tissues and in heart, placenta, liver, lung, appendix, and kidney, and no expression seen in fetal tissues, endocrine glands, or nonhematopoietic tumor lines.
  • Sequence similarities
    Belongs to the tumor necrosis factor family.
  • Post-translational
    modifications
    N-glycosylated.
    The soluble form of isoform 1 derives from the membrane form by proteolytic processing.
  • Cellular localization
    Cytoplasm; Secreted and Cell membrane.
  • Information by UniProt

References for Recombinant Human LIGHT protein (ab82123)

ab82123 has not yet been referenced specifically in any publications.

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Reconstitution: Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. For ext...

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