Hydrolyzes specifically phosphatidic acid (PA) to produce 2-acyl lysophosphatidic acid (LPA; a potent bioactive lipid mediator) and fatty acid. Does not hydrolyze other phospholipids, like phosphatidylserine (PS), phosphatidylcholine (PC) and phosphatidylethanolamine (PE) or triacylglycerol (TG).
Expressed in testis. Expressed exclusively at the connecting piece of the sperm.
Involvement in disease
Defects in LIPI may be a cause of susceptibility to familial hypertriglyceridemia (FHTR)[MIM:145750]. Familial hypertriglyceridemia is a common inherited disorder in which the concentration of very low density lipoprotein (VLDL) is elevated in the plasma. This leads to increased risk of heart disease, obesity, and pancreatitis.
Belongs to the AB hydrolase superfamily. Lipase family.
Phosphorylated upon DNA damage, probably by ATM or ATR.
Membrane. May associate with lipid draft and Membrane. Secreted. May associate with lipid draft.