This product is an active protein and may elicit a biological response in vivo, handle with caution.
Arginase type I
Liver type arginase
Type I arginase
Nitrogen metabolism; urea cycle; L-ornithine and urea from L-arginine: step 1/1.
Involvement in disease
Defects in ARG1 are the cause of argininemia (ARGIN) [MIM:207800]; also known as hyperargininemia. Argininemia is a rare autosomal recessive disorder of the urea cycle. Arginine is elevated in the blood and cerebrospinal fluid, and periodic hyperammonemia occurs. Clinical manifestations include developmental delay, seizures, mental retardation, hypotonia, ataxia, progressive spastic quadriplegia.