Overview

Description

  • Nature
    Recombinant
  • Source
    Baculovirus infected Sf9 cells
  • Amino Acid Sequence
    • Accession
    • Species
      Human
    • Molecular weight
      85 kDa including tags
    • Amino acids
      1 to 433

Specifications

Our Abpromise guarantee covers the use of ab119736 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Western blot

    SDS-PAGE

  • Purity
    > 90 % SDS-PAGE.
    The purity was determined to be 90% by densitometry
  • Form
    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 7.50
    Constituents: 0.31% Glutathione, 0.002% PMSF, 0.003% DTT, 0.79% Tris HCl, 0.003% EDTA, 25% Glycerol, 0.29% Sodium chloride

General Info

  • Alternative names
    • hLKB1
    • Liver kinase B1
    • LKB1
    • PJS
    • Polarization related protein LKB1
    • Renal carcinoma antigen NY-REN-19
    • Serine/Threonine Kinase 11
    • Serine/threonine protein kinase 11
    • Serine/threonine protein kinase LKB1
    • Serine/threonine protein kinase STK11
    • Serine/threonine-protein kinase 11
    • Serine/threonine-protein kinase LKB1
    • Serine/threonine-protein kinase XEEK1
    • Stk11
    • STK11_HUMAN
    see all
  • Function
    Essential role in G1 cell cycle arrest. Phosphorylates and activates members of the AMPK-related subfamily of protein kinases. Tumor suppressor.
  • Tissue specificity
    Ubiquitously expressed. Strongest expression in testis and fetal liver.
  • Involvement in disease
    Defects in STK11 are a cause of Peutz-Jeghers syndrome (PJS) [MIM:175200]. PJS is a rare hereditary disease in which there is predisposition to benign and malignant tumors of many organ systems. PJS is an autosomal dominant disorder characterized by melanocytic macules of the lips, multiple gastrointestinal hamartomatous polyps and an increased risk for various neoplasms, including gastrointestinal cancer.
    Defects in STK11 have been associated with testicular tumors (TEST) [MIM:273300]. A common solid malignancy in males. Germ cell tumors of the testis constitute 95% of all testicular neoplasms.
  • Sequence similarities
    Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. LKB1 subfamily.
    Contains 1 protein kinase domain.
  • Post-translational
    modifications
    Phosphorylated by a cAMP-dependent protein kinase.
  • Cellular localization
    Nucleus. Cytoplasm. Relocates to the cytoplasm when bound to CAB39 and STRAD or CAB39 and ALS2CR2.
  • Information by UniProt

Recombinant Human LKB1 protein images

  • The purity was determined to be >90% by densitometry.

References for Recombinant Human LKB1 protein (ab119736)

ab119736 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab119736.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

Sign up