Overview

Description

  • NatureRecombinant
  • SourceBaculovirus infected Sf9 cells
  • Amino Acid Sequence
    • AccessionQ15831
    • SpeciesHuman
    • Molecular weight85 kDa including tags
    • Amino acids1 to 433

Specifications

Our Abpromise guarantee covers the use of ab119736 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Western blot

    SDS-PAGE

  • Purity> 90 % SDS-PAGE.
    The purity was determined to be 90% by densitometry
  • FormLiquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 7.50
    Constituents: 0.31% Glutathione, 0.002% PMSF, 0.003% DTT, 0.79% Tris HCl, 0.003% EDTA, 25% Glycerol, 0.29% Sodium chloride

General Info

  • Alternative names
    • hLKB1
    • Liver kinase B1
    • LKB1
    • PJS
    • Polarization related protein LKB1
    • Renal carcinoma antigen NY-REN-19
    • Serine/Threonine Kinase 11
    • Serine/threonine protein kinase 11
    • Serine/threonine protein kinase LKB1
    • Serine/threonine protein kinase STK11
    • Serine/threonine-protein kinase 11
    • Serine/threonine-protein kinase LKB1
    • Serine/threonine-protein kinase XEEK1
    • Stk11
    • STK11_HUMAN
    see all
  • FunctionEssential role in G1 cell cycle arrest. Phosphorylates and activates members of the AMPK-related subfamily of protein kinases. Tumor suppressor.
  • Tissue specificityUbiquitously expressed. Strongest expression in testis and fetal liver.
  • Involvement in diseaseDefects in STK11 are a cause of Peutz-Jeghers syndrome (PJS) [MIM:175200]. PJS is a rare hereditary disease in which there is predisposition to benign and malignant tumors of many organ systems. PJS is an autosomal dominant disorder characterized by melanocytic macules of the lips, multiple gastrointestinal hamartomatous polyps and an increased risk for various neoplasms, including gastrointestinal cancer.
    Defects in STK11 have been associated with testicular tumors (TEST) [MIM:273300]. A common solid malignancy in males. Germ cell tumors of the testis constitute 95% of all testicular neoplasms.
  • Sequence similaritiesBelongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. LKB1 subfamily.
    Contains 1 protein kinase domain.
  • Post-translational
    modifications
    Phosphorylated by a cAMP-dependent protein kinase.
  • Cellular localizationNucleus. Cytoplasm. Relocates to the cytoplasm when bound to CAB39 and STRAD or CAB39 and ALS2CR2.
  • Information by UniProt

Recombinant Human LKB1 protein images

  • The purity was determined to be >90% by densitometry.

References for Recombinant Human LKB1 protein (ab119736)

ab119736 has not yet been referenced specifically in any publications.

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