Recombinant Human Loricrin protein (ab114261)

Overview

Description

  • NatureRecombinant
  • SourceWheat germ
  • Amino Acid Sequence
    • AccessionP23490
    • SpeciesHuman
    • SequenceMSYQKKQPTPQPPVDCVKTSGGGGGGGGGGGGGCGFFGGGGSGGGSSGSG CGYSGGGGYSGGGCG GGSSGGGGGGGIGGCGGGSGGSVKYSGGGGSSG GGSGCFSSGGGGSGCFSSGGGGSSGGGSGCFS SGGGGSSGGGSGCFSS GGGGFSGQAVQCQSYGGVSSGGSSGGGSGCFSSGGGGGSVCGYSGGGSG GGSGCGGGSSGGSGSGYVSSQQVTQTSCAPQPSYGGGSSGGGGSGGSGC FSSGGGGGSSGCGGGS SGIGSGCIISGGGSVCGGGSSGGGGGGSSVGG SGSGKGVPICHQTQQKQAPTWPSK
    • Molecular weight61 kDa including tags
    • Amino acids1 to 316

Specifications

Our Abpromise guarantee covers the use of ab114261 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    ELISA

    SDS-PAGE

    Western blot

  • FormLiquid
  • Additional notesProtein concentration is above or equal to 0.05 µg/µl
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.3% Glutathione, 0.79% Tris HCl

General Info

  • Alternative names
    • LOR
    • LOR protein
    • LORI_HUMAN
    • Loricrin
    • LRN
    • MGC111513
    • OTTHUMP00000015823
    see all
  • FunctionMajor keratinocyte cell envelope protein.
  • Involvement in diseaseDefects in LOR are a cause of progressive symmetric erythrokeratodermia (PSEK) [MIM:133200]. Erythrokeratodermas are a group of disorders characterized by widespread erythematous plaques, either stationary or migratory, associated with features that include palmoplantar keratoderma. PSEK is characterized by erythematous and hyperkeratotic plaques.
    Defects in LOR are the cause of Vohwinkel syndrome with ichthyosis (VSI) [MIM:604117]; also known as loricrin keratoderma (LK) or mutilating keratoderma with ichthyosis. VSI is an ichthyotic variant of Vohwinkel syndrome (VS) characterized by progressive symmetric erythrokeratoderma or congenital ichthyosiform erythroderma born as a collodion baby. Common clinical features include hyperkeratosis of the palms and soles with digital constriction.
  • Post-translational
    modifications
    Substrate of transglutaminases. Some glutamines and lysines are cross-linked to other loricrin molecules and to SPRRs proteins.
    Contains inter- or intramolecular disulfide-bonds.
  • Cellular localizationCytoplasm. Nucleus > nucleoplasm.
  • Information by UniProt

Recombinant Human Loricrin protein images

  • ab114261 analysed by 12.5% SDS-PAGE and stained with Coomassie Blue.

References for Recombinant Human Loricrin protein (ab114261)

ab114261 has not yet been referenced specifically in any publications.

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