Transforming growth factor beta-1-binding protein 1
Transforming growth factor beta-1-masking protein large subunit
May be involved in the assembly, secretion and targeting of TGFB1 to sites at which it is stored and/or activated. May play critical roles in controlling and directing the activity of TGFB1. May have a structural role in the extra cellular matrix (ECM).
Isoform Long is found in fibroblasts.
Belongs to the LTBP family. Contains 18 EGF-like domains. Contains 4 TB (TGF-beta binding) domains.
Associates covalently with small latent TGF-beta complex via domain TB 3.
Contains hydroxylated asparagine residues. Isoform Short N-terminus is blocked. The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.