Recombinant Human Lunatic Fringe protein (ab116899)

Overview

  • Product name
    Recombinant Human Lunatic Fringe protein
  • Protein length
    Full length protein

Description

  • Nature
    Recombinant
  • Source
    Wheat germ
  • Amino Acid Sequence
    • Accession
    • Species
      Human
    • Sequence
      MTPGRCCLAADIQVETFIFTDGEDEALARHTGNVVITNCSAAHSRQALSC KMAVEYDRFIESGRKWFCHVDDDNYVNLRALLRLLASYPHTRDVYVGKPS LDRPIQAMERVSENKVRPVHFWFATGGAGFCISRGLALKMSPWASGGHFM NTAERIRLPDDCTIGYIVEALLGVPLIRSGLFHSHLENLQQVPTSELHEQ VTLSYGMFENKRNAVHVKGPFSVEADPSRFRSIHCHLYPDTPWCPRTAIF
    • Molecular weight
      53 kDa including tags
    • Amino acids
      1 to 250

Specifications

Our Abpromise guarantee covers the use of ab116899 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    ELISA

    SDS-PAGE

    Western blot

  • Form
    Liquid
  • Additional notes
    Protein concentration is above or equal to 0.05 mg/ml.
    Best use within three months from the date of receipt of this protein.
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.3% Glutathione, 0.79% Tris HCl

General Info

  • Alternative names
    • 3-N-acetylglucosaminyltransferase lunatic fringe
    • Beta-1
    • Beta-13-N-acetylglucosaminyltransferase lunatic fringe
    • lfng
    • LFNG_HUMAN
    • O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
    • SCDO3
    see all
  • Function
    Glycosyltransferase that initiates the elongation of O-linked fucose residues attached to EGF-like repeats in the extracellular domain of Notch molecules. Decreases the binding of JAGGED1 to NOTCH2 but not that of DELTA1. Essential mediator of somite segmentation and patterning.
  • Involvement in disease
    Defects in LFNG are the cause of spondylocostal dysostosis type 3 (SCDO3) [MIM:609813]. An autosomal recessive condition of variable severity associated with vertebral and rib segmentation defects. The main skeletal malformations include fusion of vertebrae, hemivertebrae, fusion of certain ribs, and other rib malformations. Deformity of the chest and spine (severe scoliosis, kyphoscoliosis and lordosis) is a natural consequence of the malformation and leads to a dwarf-like appearance. As the thorax is small, infants frequently have respiratory insufficiency and repeated respiratory infections resulting in life-threatening complications in the first year of life.
  • Sequence similarities
    Belongs to the glycosyltransferase 31 family.
  • Post-translational
    modifications
    A soluble form may be derived from the membrane form by proteolytic processing.
  • Cellular localization
    Golgi apparatus membrane.
  • Information by UniProt

Recombinant Human Lunatic Fringe protein images

  • 12.5% SDS-PAGE showing ab116899 at approximately 53.24 kDa stained with Coomassie Blue.

References for Recombinant Human Lunatic Fringe protein (ab116899)

ab116899 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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