Overview

Description

  • Nature
    Recombinant
  • Source
    Wheat germ
  • Amino Acid Sequence
    • Species
      Human
    • Sequence
      MAIVQTLPVPLEPAPEAATAPQAPVMGSVSSLISGRPCPGGPAPPRHHGP PGPTFFRQQDGLLRGGYEAQEPLCPAVPPRKAVPVTSFTYINEDFRTESP PSPSSDVEDAREQRAHNAHLRGPPPKLIPVSGKLEKNMEKILIRPTAFKP VLPKPRGAPSLPSFMGPRATGLSGSQGSLTQLFGGPASSSSSSSSSSAAD KPLAFSGWASGCPSGTLSDSGRNSLSSLPTYSTGGAEPTTSSPGGHLPSH GSGRGALPGPARGVPTGPSHSDSGRSSSSKSTGSLGGRVAGGLLGSGTRA SPDSSSCGERSPPPPPPPPSDEALLHCVLEGKLRDREAELQQLRDSLDEN EATMCQAYEERQRHWQREREALREDCAAQAQRAQRAQQLLQLQVFQLQQE KRQLQDDFAQLLQEREQLERRCATLEREQRELGPRLEETKWEVCQKSGEI SLLKQQLKESQAELVQKGSELVALRVALREARATLRVSEGRARGLQEAAR ARELELEACSQELQRHRQEAEQLREKAGQLDAEAAGLREPPVPPATADPF LLAESDEAKVQRAAAGVGGSLRAQVERLRVELQRERRRGEEQRDSFEGER LAWQAEKEQVIRYQKQLQHNYIQMYRRNRQLEQELQQLSLELEARELADL GLAEQAPCICLEEITATEI
    • Amino acids
      1 to 669
    • Tags
      proprietary tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab164592 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Western blot

    ELISA

  • Form
    Liquid
  • Additional notes
    Protein concentration is above or equal to 0.05 mg/ml.
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.31% Glutathione, 0.79% Tris HCl

General Info

  • Alternative names
    • hLZTS2
    • KIAA1813
    • LAPSER1
    • Leucine zipper putative tumor suppressor 2
    • LZTS2
    • LZTS2_HUMAN
    • OTTHUMP00000020289
    • Protein LAPSER1
    • RP11-108L7.8
    see all
  • Function
    Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle formation and the completion of cytokinesis. May negatively regulate axonal outgrowth by preventing the formation of microtubule bundles that are necessary for transport within the elongating axon. Negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta-catenin.
  • Tissue specificity
    Highly expressed in prostate and testis, and at slightly lower levels in spleen, thymus, uterus, small intestine and colon.
  • Sequence similarities
    Belongs to the LZTS2 family.
  • Cellular localization
    Cytoplasm. Cytoplasm > cytoskeleton > centrosome. Localized to the centrosome throughout the cell cycle. Localized to the midbody in cells undergoing cytokinesis.
  • Information by UniProt

Images

  • ab164592 on a 12.5% SDS-PAGE stained with Coomassie Blue.

References

ab164592 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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