The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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Preparation and Storage
Stability and Storage
Shipped at 4°C. Store at +4°C.
Constituents: 10% Trehalose, 1% Human serum albumin, PBS
It is recommended that 0.5 ml of sterile phosphate-buffered saline be added to the vial. Working concentrations should be less than 100ng/ml to avoid aggregation.
Following reconstitution short-term storage at 4°C is recommended, and longer-term storage of aliquots at -18 to -20°C. Repeated freeze thawing is not recommended.
MIP 1 beta
Secreted protein G 26
C C motif chemokine 4
C C motif chemokine 4 like
C C motif chemokine ligand 4 like 1
C C motif chemokine ligand 4 like 2
CC chemokine ligand 4
CC chemokine ligand 4L1
CC chemokine ligand 4L1d2
CC chemokine ligand 4L2
Chemokine (C C motif) ligand 4
Chemokine (C C motif) ligand 4 like 1
Chemokine (C C motif) ligand 4 like 1, telomeric
Chemokine (C C motif) ligand 4 like 2
Chemokine CC Motif Ligand 4
G 26 T lymphocyte secreted protein
G-26 T-lymphocyte-secreted protein
Immune activation 2
Lymphocyte activation gene 1
Lymphocyte activation gene 1 protein
Macrophage inflammatory protein 1 beta
Macrophage inflammatory protein 1-beta
Macrophage inflammatory protein 1b2
Monocyte adherence induced protein 5 alpha
Secreted protein G 26
Secreted protein G26
Small inducible cytokine A4
Small inducible cytokine A4 (homologous to mouse Mip 1b)
small inducible cytokine A4-like
Small-inducible cytokine A4
T cell activation protein 2
T-cell activation protein 2
Monokine with inflammatory and chemokinetic properties. Binds to CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-beta induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form MIP-1-beta(3-69) retains the abilities to induce down-modulation of surface expression of the chemokine receptor CCR5 and to inhibit the CCR5-mediated entry of HIV-1 in T-cells. MIP-1-beta(3-69) is also a ligand for CCR1 and CCR2 isoform B.
Belongs to the intercrine beta (chemokine CC) family.
N-terminal processed form MIP-1-beta(3-69) is produced by proteolytic cleavage after secretion from peripheral blood lymphocytes.