The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
The biological activity of this product is determined by its ability to chemoattract human monocytes using a concentration range of 5.0 - 20.0 ng/mL.
Endotoxin level< 0.100 Eu/µg
% SDS-PAGE. Sterile filtered. Greater than 99% by SDS-PAGE and HPLC analyses.
Concentration information loading...
Preparation and Storage
Stability and Storage
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
This product is an active protein and may elicit a biological response in vivo, handle with caution.
ReconstitutionPlease reconstitute in 100ul sterile water.
MIP 1 beta
Secreted protein G 26
C C motif chemokine 4
C C motif chemokine 4 like
CC chemokine ligand 4
CC chemokine ligand 4L1
CC chemokine ligand 4L1d2
CC chemokine ligand 4L2
Chemokine (C C motif) ligand 4
Chemokine (C C motif) ligand 4 like 1
Chemokine (C C motif) ligand 4 like 1, telomeric
Chemokine (C C motif) ligand 4 like 2
Chemokine CC Motif Ligand 4
G 26 T lymphocyte secreted protein
G-26 T-lymphocyte-secreted protein
Immune activation 2
Lymphocyte activation gene 1
Lymphocyte activation gene 1 protein
Macrophage inflammatory protein 1 beta
Macrophage inflammatory protein 1-beta
Macrophage inflammatory protein 1b2
Monocyte adherence induced protein 5 alpha
Secreted protein G 26
Secreted protein G26
Small inducible cytokine A4
Small inducible cytokine A4 (homologous to mouse Mip 1b)
small inducible cytokine A4-like
Small-inducible cytokine A4
T cell activation protein 2
T-cell activation protein 2
FunctionMonokine with inflammatory and chemokinetic properties. Binds to CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-beta induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form MIP-1-beta(3-69) retains the abilities to induce down-modulation of surface expression of the chemokine receptor CCR5 and to inhibit the CCR5-mediated entry of HIV-1 in T-cells. MIP-1-beta(3-69) is also a ligand for CCR1 and CCR2 isoform B.
Sequence similaritiesBelongs to the intercrine beta (chemokine CC) family.
Post-translational modificationsN-terminal processed form MIP-1-beta(3-69) is produced by proteolytic cleavage after secretion from peripheral blood lymphocytes.