The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Endotoxin level< 0.100 Eu/µg
Additional notesThe biological activity of this product is determined by its ability to chemoattract human T-cells using a concentration range of 10.0-50.0 ng/ml.
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Preparation and Storage
Stability and Storage
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
This product is an active protein and may elicit a biological response in vivo, handle with caution.
C C motif chemokine ligand 23
C-C motif chemokine 23
C6 beta chemokine
Chemokine (C C motif) ligand 23
Chemokine CC motif ligand 23
ck beta 8
Macrophage inflammatory protein 3
Myeloid progenitor inhibitory factor 1
Small inducible cytokine A 23
Small inducible cytokine subfamily A (Cys-Cys), member 23
Small inducible cytokine subfamily A, member 23
Small-inducible cytokine A23
FunctionShows chemotactic activity for monocytes, resting T-lymphocytes, and neutrophils, but not for activated lymphocytes. Inhibits proliferation of myeloid progenitor cells in colony formation assays. This protein can bind heparin. Binds CCR1. CCL23(19-99), CCL23(22-99), CCL23(27-99), CCL23(30-99) are more potent chemoattractants than the small-inducible cytokine A23.
Tissue specificityHigh levels in adult lung, liver, skeletal muscle and pancreas. Moderate levels in fetal liver, adult bone marrow and placenta. The short form is the major species and the longer form was detected only in very low abundance. CCL23(19-99), CCL23(22-99), CCL23(27-99), CCL23(30-99) are found in high levels in synovial fluids from rheumatoid patients.
Sequence similaritiesBelongs to the intercrine beta (chemokine CC) family.