The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Protein concentration is above or equal to 0.05 mg/ml.
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Preparation and Storage
Stability and Storage
Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
pH: 8.00 Constituents: 0.31% Glutathione, 0.79% Tris HCl
MAD1 mitotic arrest deficient like 1 (yeast)
MAD1-like protein 1
Mitotic arrest deficient 1
Mitotic arrest deficient 1-like protein 1
Mitotic checkpoint MAD1 protein homolog
Mitotic spindle assembly checkpoint protein MAD1
Tax binding protein 181
Tax-binding protein 181
Tumor protein p53 inducible protein 9
Component of the spindle-assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. May recruit MAD2L1 to unattached kinetochores. Has a role in the correct positioning of the septum. Required for anchoring MAD2L1 to the nuclear periphery. Binds to the TERT promoter and represses telomerase expression, possibly by interfering with MYC binding.
Expressed weakly at G0/G1 and highly at late S and G2/M phase.
Involvement in disease
Defects in MAD1L1 are involved in the development and/or progression of various types of cancer.
Belongs to the MAD1 family.
Phosphorylated; by BUB1. Become hyperphosphorylated in late S through M phases or after mitotic spindle damage.
Nucleus. Chromosome > centromere > kinetochore. Cytoplasm > cytoskeleton > microtubule organizing center > centrosome. Cytoplasm > cytoskeleton > spindle. From the beginning to the end of mitosis, it is seen to move from a diffusely nuclear distribution to the centrosome, to the spindle midzone and finally to the midbody. Colocalizes with NEK2 at the kinetochore.