Recombinant Human MAD2L1 binding protein (ab123183)

Overview

  • Product nameRecombinant Human MAD2L1 binding protein
  • Protein lengthFull length protein

Description

  • NatureRecombinant
  • SourceEscherichia coli
  • Amino Acid Sequence
    • AccessionQ15013
    • SpeciesHuman
    • SequenceMGSSHHHHHH SSGLVPRGSH MGSHMAAPEA EVLSSAAVPD LEWYEKSEET HASQIELLET SSTQEPLNAS EAFCPRDCMV PVVFPGPVSQ EGCCQFTCEL LKHIMYQRQQ LPLPYEQLKH FYRKPSPQAE EMLKKKPRAT TEVSSRKCQQ ALAELESVLS HLEDFFARTL VPRVLILLGG NALSPKEFYE LDLSLLAPYS VDQSLSTAAC LRRLFRAIFM ADAFSELQAP PLMGTVVMAQ GHRNCGEDWF RPKLNYRVPS RGHKLTVTLS CGRPSIRTTA WEDYIWFQAP VTFKGFRE
    • Molecular weight34 kDa including tags
    • Amino acids1 to 274
    • TagsHis tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab123183 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

    Mass Spectrometry

  • Mass spectrometry
    MALDI-TOF
  • Purity> 90 % SDS-PAGE.
    ab123183 was purified using conventional chromatography techniques.
  • FormLiquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

    pH: 8.00
    Constituents: 0.02% DTT, 0.32% Tris HCl, 10% Glycerol, 0.58% Sodium chloride

General Info

  • Alternative names
    • Caught by MAD2 protein
    • CMT2
    • dJ261G23.1
    • KIAA0110
    • MAD2L1 binding protein
    • MAD2L1 binding protein isoform 2
    • MAD2L1-binding protein
    • Mad2l1bp
    • MD2BP_HUMAN
    • MGC11282
    • OTTHUMP00000016496
    • RP1 261G23.6
    see all
  • FunctionMay function to silence the spindle checkpoint and allow mitosis to proceed through anaphase by binding MAD2L1 after it has become dissociated from the MAD2L1-CDC20 complex.
  • Sequence similaritiesBelongs to the MAD2L1BP family.
  • Developmental stageDuring the cell cycle, levels increase and then remain constant until late mitosis after which they drop.
  • Post-translational
    modifications
    Phosphorylated upon DNA damage, probably by ATM or ATR.
  • Cellular localizationNucleus. Cytoplasm > cytoskeleton > spindle. During early mitosis, unevenly distributed throughout the nucleoplasm. From metaphase to anaphase, concentrated on the spindle.
  • Information by UniProt

Recombinant Human MAD2L1 binding protein images

  • 15% SDS-PAGE showing ab123183 (3µg). (Molecular size on SDS-PAGE will appear higher than predicted)

References for Recombinant Human MAD2L1 binding protein (ab123183)

ab123183 has not yet been referenced specifically in any publications.

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