Overview

Description

  • NatureRecombinant
  • SourceEscherichia coli
  • Amino Acid Sequence
    • AccessionO15525
    • SpeciesHuman
    • Molecular weight20 kDa including tags
    • Amino acids1 to 162
    • TagsHis tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab113589 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

    Mass Spectrometry

  • Mass spectrometry
    MALDI-TOF
  • Purity> 90 % SDS-PAGE.
    ab113589 was purified by using conventional chromatography.
  • FormLiquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

    pH: 8.00
    Constituents: 0.32% Tris HCl, 40% Glycerol, 0.88% Sodium chloride, 0.02% DTT

General Info

  • Alternative names
    • AA545192
    • Basic leucine zipper transcription factor MafG
    • C630022N07Rik
    • hMAF
    • MAFG
    • MAFG v maf musculoaponeurotic fibrosarcoma oncogene homolog G (avian)
    • MAFG_HUMAN
    • MGC13090
    • MGC20149
    • RP23 84C12.9
    • Transcription factor MafG
    • V maf musculoaponeurotic fibrosarcoma oncogene homolog G
    • V-maf musculoaponeurotic fibrosarcoma oncogene homolog G
    see all
  • FunctionSince they lack a putative transactivation domain, the small Mafs behave as transcriptional repressors when they dimerize among themselves. However, they seem to serve as transcriptional activators by dimerizing with other (usually larger) basic-zipper proteins and recruiting them to specific DNA-binding sites. Small Maf proteins heterodimerize with Fos and may act as competitive repressors of the NF-E2 transcription factor. Transcription factor, component of erythroid-specific transcription factor NF-E2. Activates globin gene expression when associated with NF-E2. May be involved in signal transduction of extracellular H(+).
  • Tissue specificityHighly expressed in skeletal muscle. Also expressed in heart and brain.
  • Sequence similaritiesBelongs to the bZIP family. Maf subfamily.
    Contains 1 bZIP domain.
  • Post-translational
    modifications
    Acetylated in erythroid cells by CREB-binding protein (CBP). Acetylation augments the DNA-binding activity of NFE2, but has no effect on binding NFE2.
    Sumoylation at Lys-14 is required for active transcriptional repression.
  • Cellular localizationNucleus.
  • Information by UniProt

Recombinant Human MAFG protein images

  • ab113589 at 3 µg analysed by 15% SDS-PAGE.

References for Recombinant Human MAFG protein (ab113589)

ab113589 has not yet been referenced specifically in any publications.

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