This product is an active protein and may elicit a biological response in vivo, handle with caution.
Antigen MZ2 E
Cancer/testis antigen 1.1
cancer/testis antigen family 1, member 1
MAGE 1 antigen
Melanoma antigen 1
Melanoma antigen family A 1
Melanoma antigen family A 1 (directs expression of antigen MZ2 E)
Melanoma antigen MAGE 1
Melanoma associated antigen 1
Melanoma associated antigen MZ2 E
Melanoma-associated antigen 1
FunctionMay be involved in transcriptional regulation through interaction with SNW1 and recruiting histone deactelyase HDAC1. May inhibit notch intracellular domain (NICD) transactivation. May play a role in embryonal development and tumor transformation or aspects of tumor progression. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes.
Tissue specificityExpressed in many tumors of several types, such as melanoma, head and neck squamous cell carcinoma, lung carcinoma and breast carcinoma, but not in normal tissues except for testes. Never expressed in kidney tumors, leukemias and lymphomas.