Recombinant Human MAP2K1IP1 protein (ab102022)

Overview

  • Product nameRecombinant Human MAP2K1IP1 protein
  • Protein lengthFull length protein

Description

  • NatureRecombinant
  • SourceEscherichia coli
  • Amino Acid Sequence
    • AccessionQ9UHA4
    • SpeciesHuman
    • SequenceMGSSHHHHHHSSGLVPRGSHMADDLKRFLYKKLPSVEGLHAIVVSDRDGV PVIKVANDNAPEHALRPGFLSTFALATDQGSKLGLSKNKSIICYYNTYQV VQFNRLPLVVSFIASSSANTGLIVSLEKELAPLFEELRQVVEVS
    • Molecular weight16 kDa including tags
    • Amino acids1 to 124
    • TagsHis tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab102022 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

    Mass Spectrometry

  • Mass spectrometry
    MALDI-TOF
  • Purity> 95 % SDS-PAGE.
    ab102022 was purified using conventional chromatography techniques.
  • FormLiquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    Preservative: None
    Constituents: 20% Glycerol, 5mM DTT, 20mM Tris HCl, 100mM Sodium chloride, pH 8.0

General Info

  • Alternative names
    • LAMTOR3
    • Late endosomal/lysosomal adaptor and MAPK and MTOR activator 3
    • LTOR3_HUMAN
    • MAP2K1IP1
    • MEK binding partner 1
    • MEK partner 1
    • MEK-binding partner 1
    • Mitogen activated protein kinase kinase 1 interacting protein 1
    • Mitogen-activated protein kinase kinase 1-interacting protein 1
    • Mitogen-activated protein kinase scaffold protein 1
    • Mp1
    • Ragulator complex protein LAMTOR3
    see all
  • FunctionAs part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. Adapter protein that enhances the efficiency of the MAP kinase cascade facilitating the activation of MAPK2.
  • Sequence similaritiesBelongs to the LAMTOR3 family.
  • Cellular localizationLate endosome membrane.
  • Information by UniProt

Recombinant Human MAP2K1IP1 protein images

  • 15% SDS-PAGE analysis of 3µg ab102022.

References for Recombinant Human MAP2K1IP1 protein (ab102022)

ab102022 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"