COT proto oncogene serine/threonine protein kinase
Ewing sarcoma transformant
Mitogen activated protein kinase kinase kinase 8
Mitogen-activated protein kinase kinase kinase 8
Proto oncogene cCot
Serine/threonine protein kinase cot
Serine/threonine-protein kinase cot
Tumor progression locus 2
FunctionRequired for TLR4 activation of the MEK/ERK pathway. Able to activate NF-kappa-B 1 by stimulating proteasome-mediated proteolysis of NF-kappa-B 1/p105. Plays a role in the cell cycle. The longer form has some transforming activity, although it is much weaker than the activated cot oncoprotein.
Tissue specificityExpressed in several normal tissues and human tumor-derived cell lines.
Sequence similaritiesBelongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. Contains 1 protein kinase domain.
Developmental stageIsoform 1 is activated specifically during the S and G2/M phases of the cell cycle.
Post-translational modificationsAutophosphorylated. Isoform 1 undergoes phosphorylation mainly on Ser residues, and isoform 2 on both Ser and Thr residues.