The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Additional notesProtein concentration is above or equal to 0.05 mg/ml. Best used within three months from the date of receipt.
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Preparation and Storage
Stability and Storage
Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
pH: 8.00 Constituents: 0.3% Glutathione, 0.79% Tris HCl
Mitogen activated protein kinase kinase kinase 9
Mitogen-activated protein kinase kinase kinase 9
Mixed lineage kinase 1
Mixed lineage kinase 1 (tyr and ser/thr specificity)
FunctionActivates the JUN N-terminal pathway.
Tissue specificityExpressed in epithelial tumor cell lines of colonic, breast and esophageal origin.
Sequence similaritiesBelongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. Contains 1 protein kinase domain. Contains 1 SH3 domain.
Post-translational modificationsAutophosphorylation on serine and threonine residues within the activation loop plays a role in enzyme activation. Thr-312 is likely to be the main autophosphorylation site.