This product is an active protein and may elicit a biological response in vivo, handle with caution.
Mitogen activated protein kinase kinase kinase 9
Mitogen-activated protein kinase kinase kinase 9
Mixed lineage kinase 1
Mixed lineage kinase 1 (tyr and ser/thr specificity)
FunctionActivates the JUN N-terminal pathway.
Tissue specificityExpressed in epithelial tumor cell lines of colonic, breast and esophageal origin.
Sequence similaritiesBelongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. Contains 1 protein kinase domain. Contains 1 SH3 domain.
Post-translational modificationsAutophosphorylation on serine and threonine residues within the activation loop plays a role in enzyme activation. Thr-312 is likely to be the main autophosphorylation site.