This product is an active protein and may elicit a biological response in vivo, handle with caution.
Hepatocyte progenitor kinase like/germinal center kinase like kinase
HPK/GCK like kinase
HPK/GCK like kinase HGK
HPK/GCK-like kinase HGK
MAPK/ERK kinase kinase kinase 4
MEK kinase kinase 4
Mitogen activated protein kinase kinase kinase kinase 4
Mitogen-activated protein kinase kinase kinase kinase 4
Nck interacting kinase
FunctionSerine/threonine kinase that may play a role in the response to environmental stress and cytokines such as TNF-alpha. Appears to act upstream of the JUN N-terminal pathway.
Tissue specificityAppears to be ubiquitous. Expressed in all tissue types examined. Isoform 5 appears to be more abundant in the brain. Isoform 4 is predominant in the liver, skeletal muscle and placenta.
Sequence similaritiesBelongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. Contains 1 CNH domain. Contains 1 protein kinase domain.
Post-translational modificationsPhosphorylated upon DNA damage, probably by ATM or ATR.