This product is an active protein and may elicit a biological response in vivo, handle with caution.
GCK family kinase MiNK
MAPK/ERK kinase kinase kinase 6
MEK (MAP/ERK) kinase kinase 6
MEK kinase kinase 6
Misshapen like kinase 1
Misshapen NIKs Related kinase
Misshapen/NIK related kinase
Mitogen activated protein kinase kinase kinase kinase 6
RelevanceMAP4K6 is a serine/threonine kinase belonging to the germinal center kinase (GCK) family. These kinases regulate a wide variety of cellular processes by coupling cell surface receptors to MAPK pathways. This kinase appears to act upstream of the JUN N-terminal pathway and may be involved in brain development. It may also play a role in the response to environmental stress, in cytoskeleton reorganization, cell adhesion, and cell motility. Alternative splicing occurs at this locus and four transcript variants encoding distinct isoforms have been identified.