This product is an active protein and may elicit a biological response in vivo, handle with caution.
Human p38Beta MAP kinase mRNA complete cds
MAP kinase 11
MAP kinase p38 beta
Mitogen activated protein kinase 11
Mitogen activated protein kinase p38 2
Mitogen activated protein kinase p38 beta
Mitogen-activated protein kinase 11
Mitogen-activated protein kinase p38 beta
Protein kinase mitogen activated 11
Stress activated protein kinase 2
Stress activated protein kinase 2b
Stress-activated protein kinase 2
FunctionKinase involved in a signal transduction pathway that is activated by changes in the osmolarity of the extracellular environment, by cytokines, or by environmental stress. Phosphorylates preferentially transcription factor ATF2.
Tissue specificityHighest levels in the brain and heart. Also expressed in the placenta, lung, liver, skeletal muscle, kidney and pancreas.
Sequence similaritiesBelongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily. Contains 1 protein kinase domain.
DomainThe TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.
Post-translational modificationsDually phosphorylated on Thr-180 and Tyr-182, which activates the enzyme.