The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Protein concentration is above or equal to 0.05 mg/ml.
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Preparation and Storage
Stability and Storage
Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
pH: 8.00 Constituents: 0.31% Glutathione, 0.79% Tris HCl
E3 ubiquitin protein ligase MARCH2
E3 ubiquitin-protein ligase MARCH2
Membrane associated RING CH protein II
Membrane associated ring finger (C3HC4) 2
Membrane associated RING finger protein 2
Membrane-associated RING finger protein 2
Membrane-associated RING-CH protein II
RING finger protein 172
E3 ubiquitin-protein ligase that may mediate ubiquitination of TFRC and CD86, and promote their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. May be involved in endosomal trafficking through interaction with STX6.
Protein modification; protein ubiquitination.
Contains 1 RING-CH-type zinc finger.
The RING-CH-type zinc finger domain is required for E3 ligase activity.