Recombinant Human MARCH8 protein (ab165956)

Overview

Description

  • Nature
    Recombinant
  • Source
    Wheat germ
  • Amino Acid Sequence
    • Species
      Human
    • Sequence
      QDICRICHCEGDDESPLITPCHCTGSLHFVHQACLQQWIKSSDTRCCELC KYEFIMETKLKPLRKWEKLQMTSSERR
    • Amino acids
      77 to 153
    • Tags
      proprietary tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab165956 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    ELISA

    Western blot

  • Form
    Liquid
  • Additional notes
    Protein concentration is above or equal to 0.05 mg/ml.
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.31% Glutathione, 0.79% Tris HCl

General Info

  • Alternative names
    • c MIR
    • c-MIR
    • Cellular modulator of immune recognition
    • E3 ubiquitin protein ligase MARCH8
    • E3 ubiquitin-protein ligase MARCH8
    • MARCH 8
    • MARCH VIII
    • MARCH-VIII
    • MARCH8
    • MARH8_HUMAN
    • Membrane associated RING CH protein VIII
    • Membrane associated ring finger (C3HC4) 8
    • Membrane associated RING finger protein 8
    • Membrane-associated RING finger protein 8
    • Membrane-associated RING-CH protein VIII
    • MIR
    • OTTHUMP00000058921
    • RING finger protein 178
    • RNF178
    see all
  • Function
    E3 ubiquitin-protein ligase that mediates ubiquitination of CD86 and MHC class II proteins, such as HLA-DR alpha and beta, and promotes their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. May also promote ubiquitination and endocytosis of TFRC and FAS.
  • Tissue specificity
    Broadly expressed. Present in immature dendritic cells (at protein level).
  • Pathway
    Protein modification; protein ubiquitination.
  • Sequence similarities
    Contains 1 RING-CH-type zinc finger.
  • Domain
    The RING-CH-type zinc finger domain is required for E3 ligase activity.
  • Cellular localization
    Cytoplasmic vesicle membrane. Lysosome membrane. Early endosome membrane.
  • Information by UniProt

Images

  • ab165956 on a 12.5% SDS-PAGE stained with Coomassie Blue.

References

ab165956 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab165956.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

Sign up