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Source Saccharomyces cerevisiae
Amino Acid Sequence
Sequence MSMPLHQISAIPSQDAISARVYRSKTKEKEREEQNEKTLGHFMSHSSNIS KAGSPPSAS
YVQNCP ETSKKNIFEKSPLTEPNFENKHGYGICHSDTNSSCCTEPEDTGAEIIHV Specifications
Abpromise guarantee covers the use of
in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Purity > 90
% SDS-PAGE. ab88197 was purified using affinity chromatography.
Concentration information loading... Preparation and Storage
Stability and Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Constituents: 30% Glycerol, 0.5% Triton-X-100, 50mM HEPES, 30mM Glutathione, 100mM Sodium chloride, 1mM DTT, pH 7.5
Cellular modulator of immune recognition
Function E3 ubiquitin-protein ligase that mediates ubiquitination of CD86 and MHC class II proteins, such as HLA-DR alpha and beta, and promotes their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. May also promote ubiquitination and endocytosis of TFRC and FAS.
Tissue specificity Broadly expressed. Present in immature dendritic cells (at protein level).
Pathway Protein modification; protein ubiquitination.
Sequence similarities Contains 1 RING-CH-type zinc finger.
Domain The RING-CH-type zinc finger domain is required for E3 ligase activity.
Cellular localization Cytoplasmic vesicle membrane. Lysosome membrane. Early endosome membrane.
Information by UniProt
References for Recombinant Human MARCH8 protein (ab88197)
has not yet been referenced specifically in any publications.
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"