The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Protein concentration is above or equal to 0.05 mg/ml.
Concentration information loading...
Preparation and Storage
Stability and Storage
Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
pH: 8.00 Constituents: 0.31% Glutathione, 0.79% Tris HCl
E3 ubiquitin protein ligase MARCH9
Membrane associated RING CH protein IX
membrane associated ring finger (C3HC4) 9
Membrane associated RING finger protein 9
RING finger protein 179
MARCH9 (membrane-associated RING-CH protein IX) belongs to MARCH family, which contains at least seven membrane-associated RING-CH (MARCH)proteins. All MARCH proteins are ubiquitin ligases and located to subcellular membranes, and several MARCH proteins reduce surface levels of known substrates of the viral K3 family. Two closely related proteins, MARCH-IV and MARCH-IX, reduce surface expression of MHC-I molecules. In the presence of MARCH-IV or MARCH-IX, MHC-I are ubiquitinated and rapidly internalized by endocytosis.
The functional similarity of the MARCH family and the K3 family of viral immune evasion proteins suggests that the viral immune evasion proteins were derived from MARCH proteins, a novel family of transmembrane ubiquitin ligases that seems to target glycoproteins for lysosomal destruction via ubiquitination of the cytoplasmic tail.