This product is an active protein and may elicit a biological response in vivo, handle with caution.
ELKL motif kinase
ELKL motif kinase 1
MAP/microtubule affinity regulating kinase 2
MAP/microtubule affinity-regulating kinase 2
Ser/Thr protein kinase PAR 1B
Serine/threonine protein kinase EMK
Serine/threonine protein kinase MARK2
Serine/threonine-protein kinase MARK2
FunctionRole in epithelial morphogenesis. Modulates the developmental decision to build a columnar versus a hepatic epithelial cell apparently by promoting a switch from a direct to a transcytotic mode of apical protein delivery. Essential for the asymmetric development of membrane domains of polarized epithelial cells. One or more isoforms may play a role in graft rejection.
Tissue specificityHigh levels of expression in heart, brain, skeletal muscle and pancreas, lower levels observed in lung, liver and kidney.
Sequence similaritiesBelongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. MARK subfamily. Contains 1 KA1 (kinase-associated) domain. Contains 1 protein kinase domain. Contains 1 UBA domain.
Cellular localizationCell membrane. Phosphorylated by PRKCZ in polarized epithelial cells, resulting in an interaction with YWHAZ which promotes relocation from the lateral to the apical membrane.