The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Protein concentration is above or equal to 0.05 mg/ml.
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Preparation and Storage
Stability and Storage
Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
pH: 8.00 Constituents: 0.31% Glutathione, 0.79% Tris HCl
methyl CpG binding domain protein 5
Methyl CpG binding protein MBD5
Methyl-CpG-binding domain protein 5
Methyl-CpG-binding protein MBD5
Binds to heterochromatin. Does not interact with either methylated or unmethylated DNA (in vitro).
Detected in heart, placenta, liver, skeletal muscle, kidney and pancreas.
Involvement in disease
Defects in MBD5 are the cause of mental retardation autosomal dominant type 1 (MRD1) [MIM:156200]. Mental retardation is characterized by significantly sub-average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period.