This product is an active protein and may elicit a biological response in vivo, handle with caution.
CD167 antigen-like family member A
Cell adhesion kinase
Discoidin domain receptor
Discoidin domain receptor tyrosine kinase 1
Discoidin receptor tyrosine kinase
Discoidin receptor tyrosine kinase isoform a
Epithelial discoidin domain receptor 1
Epithelial discoidin domain-containing receptor 1
Epithelial specific receptor kinase
Mammarian carcinoma kinase 10
Mammary carcinoma kinase 10
Neuroepithelial tyrosine kinase
Neurotrophic tyrosine kinase receptor type 4
Protein-tyrosine kinase 3A
Protein-tyrosine kinase RTK-6
PTK 3A protein tyrosine kinase 3A
Receptor tyrosine kinase NEP
Tyrosine kinase DDR
Tyrosine kinase receptor E
Tyrosine-protein kinase CAK
FunctionMay be involved in cell-cell interactions and recognition.
Tissue specificityDetected in T-47D, MDA-MB-175 and HBL-100 breast carcinoma cells, A431 epidermoid carcinoma cells, SW48 and SNU-C2B colon carcinoma cells and Hs 294T melanoma cells (at protein level). Expressed at low levels in most adult tissues and is highest in the brain, lung, placenta and kidney. Lower levels of expression are detected in melanocytes, heart, liver, skeletal muscle and pancreas. Abundant in breast carcinoma cell lines. In the colonic mucosa, expressed in epithelia but not in the connective tissue of the lamina propria. In the thyroid gland, expressed in the epithelium of the thyroid follicles. In pancreas, expressed in the islets of Langerhans cells, but not in the surrounding epithelial cells of the exocrine pancreas. In kidney, expressed in the epithelia of the distal tubules. Not expressed in connective tissue, endothelial cells, adipose tissue, muscle cells or cells of hematopoietic origin.
Sequence similaritiesBelongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily. Contains 1 F5/8 type C domain. Contains 1 protein kinase domain.
DomainThe Gly/Pro-rich domains may be required for an unusual geometry of interaction with ligand or substrates.