The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Protein concentration is above or equal to 0.05 µg/ul. Best use within three months from the date of receipt of this protein.
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Preparation and Storage
Stability and Storage
Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
pH: 8.00 Constituents: 0.3% Glutathione, 0.79% Tris HCl
DNA replication licensing factor MCM6
MCM6 minichromosome maintenance deficient 6
MCM6 minichromosome maintenance deficient 6 (MIS5 homolog, S. pombe)
Minichromosome maintenance complex component 6
Minichromosome maintenance deficient (mis5 S. pombe) 6
Minichromosome maintenance deficient 6 homolog
Minichromosome maintenance protein 6
Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.
Belongs to the MCM family. Contains 1 MCM domain.
Phosphorylated upon DNA damage, probably by ATM or ATR.
Nucleus. Binds to chromatin during G1 and detach from it during S phase.