Overview

Description

  • Nature
    Recombinant
  • Source
    Escherichia coli
  • Amino Acid Sequence
    • Species
      Human
    • Molecular weight
      11 kDa

Associated products

Specifications

Our Abpromise guarantee covers the use of ab9560 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Functional Studies

    SDS-PAGE

  • Endotoxin level
    < 0.100 Eu/µg
  • Form
    Lyophilised
  • Additional notes
    The biological activity of this product is determined by its ability to chemoattract human eosinophils using a concentration range of 10.0-100.0 ng/ml.
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

    n/a

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

General Info

  • Alternative names
    • C-C motif chemokine 13
    • CCL13
    • CCL13_HUMAN
    • Chemokine (C C motif) ligand 13
    • CK beta 10
    • CK-beta-10
    • CKb10
    • MCP-4
    • MGC17134
    • Monocyte chemoattractant protein 4
    • Monocyte chemotactic protein 4
    • NCC 1
    • NCC-1
    • NCC1
    • New CC chemokine 1
    • SCYA13
    • SCYL1
    • short chain
    • Small inducible cytokine A13 precursor
    • Small inducible cytokine subfamily A (Cys Cys) member 13
    • Small-inducible cytokine A13
    see all
  • Function
    Chemotactic factor that attracts monocytes, lymphocytes, basophils and eosinophils, but not neutrophils. Signals through CCR2B and CCR3 receptors. Plays a role in the accumulation of leukocytes at both sides of allergic and non-allergic inflammation. May be involved in the recruitment of monocytes into the arterial wall during the disease process of atherosclerosis. May play a role in the monocyte attraction in tissues chronically exposed to exogenous pathogens.
  • Tissue specificity
    Widely expressed. Found in small intestine, thymus, colon, lung, trachea, stomach and lymph node. Low levels seen in the pulmonary artery smooth muscle cells.
  • Sequence similarities
    Belongs to the intercrine beta (chemokine CC) family.
  • Post-translational
    modifications
    One major form (form long), and two minor forms (short chain and medium chain) are produced by differential signal peptide cleavage. The medium chain is about 30-fold less active than the long chain.
  • Cellular localization
    Secreted.
  • Information by UniProt

References

ab9560 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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