The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Endotoxin level< 0.100 Eu/µg
Additional notesThe biological activity of this product is determined by its ability to chemoattract human eosinophils using a concentration range of 10.0-100.0 ng/ml.
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Preparation and Storage
Stability and Storage
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
This product is an active protein and may elicit a biological response in vivo, handle with caution.
C-C motif chemokine 13
Chemokine (C C motif) ligand 13
CK beta 10
Monocyte chemoattractant protein 4
Monocyte chemotactic protein 4
New CC chemokine 1
Small inducible cytokine A13 precursor
Small inducible cytokine subfamily A (Cys Cys) member 13
Small-inducible cytokine A13
FunctionChemotactic factor that attracts monocytes, lymphocytes, basophils and eosinophils, but not neutrophils. Signals through CCR2B and CCR3 receptors. Plays a role in the accumulation of leukocytes at both sides of allergic and non-allergic inflammation. May be involved in the recruitment of monocytes into the arterial wall during the disease process of atherosclerosis. May play a role in the monocyte attraction in tissues chronically exposed to exogenous pathogens.
Tissue specificityWidely expressed. Found in small intestine, thymus, colon, lung, trachea, stomach and lymph node. Low levels seen in the pulmonary artery smooth muscle cells.
Sequence similaritiesBelongs to the intercrine beta (chemokine CC) family.
Post-translational modificationsOne major form (form long), and two minor forms (short chain and medium chain) are produced by differential signal peptide cleavage. The medium chain is about 30-fold less active than the long chain.