Mediator of RNA polymerase II transcription subunit 4
Mediator of RNA polymerase II transcription, subunit 4 homolog
TRAP/SMCC/PC2 subunit p36 subunit
Vitamin D3 receptor-interacting protein complex 36 kDa component
FunctionComponent of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
Sequence similaritiesBelongs to the Mediator complex subunit 4 family.