This product is an active protein and may elicit a biological response in vivo, handle with caution.
MAPK/ERK kinase kinase 1
MEK kinase 1
Mitogen activated protein kinase kinase kinase 1
Mitogen activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase
Mitogen-activated protein kinase kinase kinase 1
FunctionComponent of a protein kinase signal transduction cascade. Activates the ERK and JNK kinase pathways by phosphorylation of MAP2K1 and MAP2K4. Activates CHUK and IKBKB, the central protein kinases of the NF-kappa-B pathway.
Sequence similaritiesBelongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. Contains 1 protein kinase domain. Contains 1 RING-type zinc finger. Contains 1 SWIM-type zinc finger.