Overview

Description

  • NatureRecombinant
  • SourceBaculovirus infected Sf9 cells
  • Amino Acid Sequence
    • SpeciesHuman
    • Amino acids578 to 872

Associated products

Specifications

Our Abpromise guarantee covers the use of ab72490 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Biological activityThe Specific activity of ab72490 was determined to be 1231 nmol/min/mg.
  • Applications

    SDS-PAGE

    Functional Studies

  • FormLiquid
  • Additional notes

    ab204877 (Poly (4:1 Glu, Tyr) peptide) can be utilized as a substrate for assessing kinase activity

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: 25% Glycerol, 50mM Tris HCl, 150mM Sodium chloride, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, pH 7.5

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

General Info

  • Alternative names
    • c MER
    • c mer proto oncogene tyrosine kinase
    • c-mer
    • cMER
    • cmer protooncogene tyrosine kinase
    • Eyk
    • MER
    • MER receptor tyrosine kinase
    • MERK
    • MERPEN
    • Mertk
    • MERTK c-mer proto-oncogene tyrosine kinase
    • MERTK_HUMAN
    • MGC133349
    • nmf12
    • Nyk
    • Proto oncogene tyrosine protein kinase MER
    • Proto oncogene tyrosine protein kinase MER precursor
    • Proto-oncogene c-Mer
    • Receptor tyrosine kinase MerTK
    • RP38
    • STK kinase
    • Tyrosine-protein kinase Mer
    see all
  • FunctionIn case of filovirus infection, seems to function as a cell entry factor.
  • Tissue specificityNot expressed in normal B- and T-lymphocytes but is expressed in numerous neoplastic B- and T-cell lines.
  • Involvement in diseaseDefects in MERTK are the cause of retinitis pigmentosa type 38 (RP38) [MIM:613862]. RP38 is a retinal dystrophy belonging to the group of pigmentary retinopathies. Retinitis pigmentosa is characterized by retinal pigment deposits visible on fundus examination and primary loss of rod photoreceptor cells followed by secondary loss of cone photoreceptors. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well.
  • Sequence similaritiesBelongs to the protein kinase superfamily. Tyr protein kinase family. AXL/UFO subfamily.
    Contains 2 fibronectin type-III domains.
    Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
    Contains 1 protein kinase domain.
  • Cellular localizationMembrane.
  • Information by UniProt

Recombinant human MERTK protein images

  • Kinase Assay demonstrating specific activity of ab72490.
  • SDS-PAGE showing ab72490 at approximately 58kDa.

References for Recombinant human MERTK protein (ab72490)

ab72490 has not yet been referenced specifically in any publications.

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