This product is an active protein and may elicit a biological response in vivo, handle with caution.
c mer proto oncogene tyrosine kinase
cmer protooncogene tyrosine kinase
MER receptor tyrosine kinase
MERTK c-mer proto-oncogene tyrosine kinase
Proto oncogene tyrosine protein kinase MER
Proto oncogene tyrosine protein kinase MER precursor
Receptor tyrosine kinase MerTK
Tyrosine-protein kinase Mer
FunctionIn case of filovirus infection, seems to function as a cell entry factor.
Tissue specificityNot expressed in normal B- and T-lymphocytes but is expressed in numerous neoplastic B- and T-cell lines.
Involvement in diseaseDefects in MERTK are the cause of retinitis pigmentosa type 38 (RP38) [MIM:613862]. RP38 is a retinal dystrophy belonging to the group of pigmentary retinopathies. Retinitis pigmentosa is characterized by retinal pigment deposits visible on fundus examination and primary loss of rod photoreceptor cells followed by secondary loss of cone photoreceptors. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well.
Sequence similaritiesBelongs to the protein kinase superfamily. Tyr protein kinase family. AXL/UFO subfamily. Contains 2 fibronectin type-III domains. Contains 2 Ig-like C2-type (immunoglobulin-like) domains. Contains 1 protein kinase domain.