Recombinant Human MESDC2 protein (ab125670)

Overview

Description

  • NatureRecombinant
  • SourceEscherichia coli
  • Amino Acid Sequence
    • AccessionQ14696
    • SpeciesHuman
    • SequenceMGSSHHHHHH SSGLVPRGSH MAEGSPGTPD ESTPPPRKKK KDIRDYNDAD MARLLEQWEK DDDIEEGDLP EHKRPSAPVD FSKIDPSKPE SILKMTKKGK TLMMFVTVSG SPTEKETEEI TSLWQGSLFN ANYDVQRFIV GSDRAIFMLR DGSYAWEIKD FLVGQDRCAD VTLEGQVYPG KGGGSKEKNK TKQDKGKKKK EGDLKSRSSK EENRAGNKRE DL
    • Molecular weight25 kDa
    • Amino acids34 to 234
    • TagsHis tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab125670 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

  • Purity> 90 % SDS-PAGE.
    Purified by proprietary chromatographic techniques.
  • FormLiquid
  • Additional notesFor long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.02% DTT, 0.32% Tris HCl, 20% Glycerol, 0.58% Sodium chloride

General Info

  • Alternative names
    • BOCA
    • KIAA0081
    • LDLR chaperone MESD
    • MESD
    • MESD_HUMAN
    • MESDC 2
    • mesdc2
    • Mesoderm development candidate 2
    • Mesoderm development protein
    • Renal carcinoma antigen NY REN 61
    • Renal carcinoma antigen NY-REN-61
    see all
  • FunctionChaperone specifically assisting the folding of beta-propeller/EGF modules within the family of low-density lipoprotein receptors (LDLRs). Acts as a modulator of the Wnt pathway through chaperoning the coreceptors of the canonical Wnt pathway, LRP5 and LRP6, to the plasma membrane. Essential for specification of embryonic polarity and mesoderm induction.
  • Sequence similaritiesBelongs to the MESD family.
  • DomainThe chaperone domain provides a folding template for proper folding of the beta-propeller (BP) domains of LRP5/6.
    The escort domain ensures LRP5/6 safe-trafficking from the ER to the Golgi by preventing premature ligand-binding.
  • Cellular localizationEndoplasmic reticulum.
  • Information by UniProt

References for Recombinant Human MESDC2 protein (ab125670)

ab125670 has not yet been referenced specifically in any publications.

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